Fibrinolysis is the destruction of fibrin. Fibrin is the
insoluble protein in clotted blood. In order for blood to clot, sufficient amounts of
fibrin (and other things like calcium) must be present.
I
respectfully disagree with the second part of your question because intravascular blood
very often does in fact remain clotted inside the lumen of blood vessels. In fact, this
is the etiology of many disease processes. DVT's (deep venous thrombosis) is a good
example of this phenomenon. Clots (thrombi) develop in the deep veins of the legs for
varying reasons. This produces pain, swelling, heat, and decreased range of motion to
the affected extremity.
Another disease process that is due
to clotted blood in the blood vessels is called acute coronary syndrome. Thrombi in the
coronary arteries cause a multitude of signs and symptoms and are a major cause of
sudden cardiac death.
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