How does the plight of those outside the "Annexe" contribute to the theme that human growth involves pain?This is part of an assignment i have to...

It's a very interesting question.  I think that one of the
most profound elements of the work is how Anne conveys that while human beings can hide
and can seek sanctuary from the outside world, they can never be fully rid of it.  The
external always impacts the internal.  Anne and her family never lose sight of the fact
that the persecution and tales of horror of those caught by the Nazis can, do, and will
impact all of them.  Anne's own personal growth involves a great deal of pain and
challenge as she strives to make sense as to why what is happening is happening. 
Throughout the diary, when Anne begins to develop the concept of questioning right and
wrong and seeking to establish her own vision of justice and fairness, she always comes
back to what is happening outside the Annexe to help formulate her understandings of
totalizing reality.  The idea here is that when we, as human beings, seek to understand
who we are and the things in which we believe, we cannot do so in a vacuum and in
ignorance of what is going on outside our own annexes.  Invariably, the outside world
holds a great deal of impact on our own psyches and internal
workings.