Hemoglobin is the respiratory pigment, the red pigment, of
all vertebrates. It is present in erythrocytes, where it has a role in transport of
oxygen and CO2.
When the death of red blood cells occurs,
their membrane suffering a rupture, hemoglobin is hydrolyzed and Fe is recovered.
Porphyrin cycle bursts and the fragments are metabolized by the
liver.
After the process, for each hemoglobin molecule
metabolized is resulting a molecule of CO. It is a natural process and it is a source of
CO for the human body, carbon monoxide which is removed through the exhaled
air.
The final metabolic product is
bilirubin, a yellow pigment, whose intensity of color means
the level of destroying of erythrocytes. If the rate of degradation of hemoglobin is too
fast, it can block capillaries, mainly the kidney capillaries, causing various
diseases.
The decreased hemoglobin, not associated with the
decreasing of number of red blood cells is called anemia. Anemia has as main cause the
deficiency of Fe. Because of this deficiency, decreased synthesis of hemoglobin, red
blood cells will be hypochromic type (low-pigmented), and smaller than
normal.
In haemolysis (destruction of red blood cells
faster than synthesis), associated jaundice is caused of bilirubin metabolite and
circulating hemoglobin, which can cause kidney failure.
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