Saturday, May 9, 2015

If you have the sickle cell anemia trait, what are your chances of developing sickle cell anemia?

The genes for normal beta globin and sickle shaped beta
globin are co-dominant. A person who inherits sickle cell trait inherits one gene for
sickle cell and one gene for normal red blood cells. Therefore, they are heterozygous.
For sickle cell anemia to be present in an individual, there must be two sickle cell
genes in that person's genotype or genetic makeup. Therefore, they are homozygous for
sickle cell anemia and only make sickle shaped red blood cells. Because the
individual with sickle cell trait only has one sickle cell gene, their body will produce
half sickle shaped red blood cells and because the other gene is normal, they would also
produce half normal shaped red cells. With this situation, because some of the red cells
are normal, the symptoms you would expect of a sickle cell anemia patient- would be
lessened. Having trait is considered a benign condition although rare
complications 
can include, kidney and spleen
complications and possible sudden death during physical exertion. However, the
individual with sickle cell trait wouldn't have the crises and frequent hospital
visits that are associated  with sickle cell anemia.

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